Vasculitic neuropathy in a patient with inactive treated lepromatous leprosy.

نویسندگان

  • J R Bowen
  • A C McDougall
  • J H Morris
  • S B Lucas
  • M Donaghy
چکیده

A 46 year old Asian male with previously treated lepromatous leprosy developed a stepwise multifocal sensory disturbance 25 years later. Neurophysiology demonstrated marked deterioration from previous studies. Sural nerve biopsy disclosed a vasculitic process superimposed on inactive lepromatous leprosy. Immunocytochemical stains for mycobacterial antigen showed deposits within nerve and vessel walls. A delayed vasculitic neuropathy precipitated by persisting mycobacterial antigen is proposed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Contribution of nerve biopsy findings to the diagnosis of disabling neuropathy in the elderly. A retrospective review of 100 consecutive patients.

Peripheral neuropathy is an important factor of disability in the elderly. In order to learn more on the usefulness of intensive evaluation of patients over 65 years of age with subacute or chronic disabling peripheral neuropathy, we reviewed the clinical and nerve biopsy findings of the last 100 patients of this age group who suffered from a peripheral neuropathy severe enough to justify perfo...

متن کامل

Two microbiological relapses in a patient with lepromatous leprosy.

A lepromatous patient treated with dapsone in the pre-MDT era to the point of smear negativity (> 6 years), relapsed 5 years after stopping treatment. He was then put on WHO-MDT for multibacillary (MB) leprosy, and was treated again; he had negative slit skin smears (3 years). He again presented with a relapse of leprosy 17 years after stopping treatment, and this time he presented with borderl...

متن کامل

CASE REPORT Sensory mononeuritis: differentiating pure neural leprosy from non-systemic vasculitic neuropathy

We describe two cases of sensory mononeuritis that presented with similar past medical histories, and clinical and electrophysiological features. The two patients were females who had resided in areas endemic for leprosy (Brazil). Both developed a progressive, purely sensory, painful mononeuritis distally in the lower limbs with sensory nerve potentials asymmetrically reduced in amplitude. The ...

متن کامل

Leprosy mimicking basal cell carcinoma in a patient on fingolimod

BCC: basal cell carcinoma ENL: erythema nodosum leprosum LL: lepromatous leprosy MS: multiple sclerosis INTRODUCTION Leprosy, also known as Hansen disease, is a chronic bacterial disease caused by Mycobacterium leprae. M. leprae has low pathogenicity and virulence, developing over many months to even decades, and has the potential to cause extensive damage to the skin and peripheral nervous sys...

متن کامل

Expression of Matrix Metalloproteinases (MMP-3 and MMP-9) in Skin Lesions of Leprosy Patients

Background. Leprosy is a chronic granulomatous disease, caused by Mycobacterium leprae (M. leprae), principally affecting peripheral nerves and skin. To date, the role of matrix metalloproteinases (MMPs) in different types of leprosy has not been studied, except for their role in neuropathy. Objective. to investigate the changes in expression and distribution of MMP-3 and MMP-9 in biopsies take...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of neurology, neurosurgery, and psychiatry

دوره 68 4  شماره 

صفحات  -

تاریخ انتشار 2000